Catalog: YT4345
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
Smo
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
86kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Smo Polyclonal Antibody detects endogenous levels of Smo protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
86kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human SMO. AA range:68-117
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Specificity:
Smo Polyclonal Antibody detects endogenous levels of Smo protein.
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Gene Name:
SMO
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Protein Name:
Smoothened homolog
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Other Name:
SMO ;
SMOH ;
Smoothened homolog ;
SMO ;
Protein Gx
SMOH ;
Smoothened homolog ;
SMO ;
Protein Gx
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Database Link:
Background:
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010],
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Function:
Disease:Defects in SMO are involved in basal cell carcinoma (BCC).,Function:G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,
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Cellular Localization:
Membrane ; Multi-pass membrane protein . Cell projection, cilium .
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Tissue Expression:
Brain,Embryonic lung,Synovial membrane,
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Research Areas:
>>Hedgehog signaling pathway ;
>>Axon guidance ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Basal cell carcinoma
>>Axon guidance ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Basal cell carcinoma
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT4345
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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