Catalog: YT2983
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
NBK
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
30 25kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
NBK Polyclonal Antibody detects endogenous levels of NBK protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
30
25kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human BIK. AA range:18-67
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Specificity:
NBK Polyclonal Antibody detects endogenous levels of NBK protein.
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Gene Name:
BIK
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Protein Name:
Bcl-2-interacting killer
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Other Name:
BIK ;
NBK ;
Bcl-2-interacting killer ;
Apoptosis inducer NBK ;
BIP1 ;
BP4
NBK ;
Bcl-2-interacting killer ;
Apoptosis inducer NBK ;
BIP1 ;
BP4
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Background:
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011],
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Function:
Domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,Function:Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.,subcellular location:Around the nuclear envelope, and in cytoplasmic membranes.,
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Cellular Localization:
Endomembrane system; Single-pass membrane protein. Mitochondrion membrane ; Single-pass membrane protein . Around the nuclear envelope, and in cytoplasmic membranes.
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Tissue Expression:
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Research Areas:
>>Endocrine resistance
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Reference Citation({{totalcount}})
Catalog: YT2983
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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