Catalog: YP1687
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
QIK/QSK Phospho Thr175/163
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
105kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of QIK/QSK only when phosphorylated at Thr175 or 163,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LAtWC
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
105kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human QIK/QSK (Phospho-Thr175/163)
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Specificity:
This antibody detects endogenous levels of QIK/QSK only when phosphorylated at Thr175 or 163,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LAtWC
show all
Gene Name:
SIK2 KIAA0781 QIK SNF1LK2
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Protein Name:
QIK/QSK (Phospho-Thr175/163)
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Other Name:
Serine/threonine-protein kinase SIK2 ;
Qin-induced kinase ;
Salt-inducible kinase 2 ;
SIK-2 ;
Serine/threonine-protein kinase SNF1-like kinase 2 ;
Qin-induced kinase ;
Salt-inducible kinase 2 ;
SIK-2 ;
Serine/threonine-protein kinase SNF1-like kinase 2 ;
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,Function:Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subunit:Interacts with and phosphorylates TORC2/CRTC2.,
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Cellular Localization:
Cytoplasm . Endoplasmic reticulum membrane .
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Tissue Expression:
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Research Areas:
>>Glucagon signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1687
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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