The antiserum was produced against synthesized peptide derived from human Histamine H1 Receptor around the phosphorylation site of Ser398. AA range:364-413

Phospho-Histamine H1 Receptor (S398) Polyclonal Antibody detects endogenous levels of Histamine H1 Receptor protein only when phosphorylated at S398.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SHsRQ

HRH1

Histamine H1 receptor

HRH1 ;
Histamine H1 receptor ;
H1R ;
HH1R

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by Ref

Function:In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.,PTM:Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in regulating signal transduction through the receptor molecule.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Cell membrane ; Multi-pass membrane protein .

Lens epithelium,Lung,

>>Calcium signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Inflammatory mediator regulation of TRP channels