Catalog: YN8588
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
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Main Information
Target
THEM4
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
26kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of CTMP at Human, Mouse,Rat
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
26kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human CTMP
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Specificity:
This antibody detects endogenous levels of CTMP at Human, Mouse,Rat
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Gene Name:
THEM4 CTMP
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Protein Name:
Thioesterase superfamily member 4 (Carboxyl-terminal modulator protein)
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Database Link:
Function:
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.
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Cellular Localization:
Cell membrane . Cell projection, ruffle membrane . Cytoplasm . Mitochondrion . Mitochondrion inner membrane; Peripheral membrane protein . Mitochondrion intermembrane space . Released from the mitochondria into the cytosol in response to apoptotic stimuli. .
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Tissue Expression:
Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YN8588
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
Collect
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