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REDD1 Rabbit pAb

-YN5726

Catalog: YN5726
Size
Price
Status
Qty.
200μL
$450.00
In stock

0

100μL
$280.00
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40μL
$160.00
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Main Information
Target

DDIT4

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB

MW

26kD (Calculated)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of REDD1 at Human, Mouse,Rat
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
26kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human REDD1
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Specificity:
This antibody detects endogenous levels of REDD1 at Human, Mouse,Rat
show all
Gene Name:
DDIT4 REDD1 RTP801
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Protein Name:
DNA damage-inducible transcript 4 protein (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)
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Database Link:
Organism Gene ID SwissProt
Human 54541; Q9NX09;
Mouse 74747; Q9D3F7;
Rat 140942; Q8VHZ9;
Function:
Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.
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Cellular Localization:
Mitochondrion . Cytoplasm, cytosol .
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Tissue Expression:
Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level).
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Catalog: YN5726
Size
Price
Status
Qty.
200μL
$450.00
In stock

0

100μL
$280.00
In stock

0

40μL
$160.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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