Catalog: YN3225
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
TTC22
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
65kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of IL1AP at Human/Mouse/Rat
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
65kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human IL1AP AA range: 213-263
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Specificity:
This antibody detects endogenous levels of IL1AP at Human/Mouse/Rat
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Gene Name:
IL1RAP C3orf13 IL1R3
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Protein Name:
IL1AP
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Other Name:
Interleukin-1 receptor accessory protein ;
IL-1 receptor accessory protein ;
IL-1RAcP ;
Interleukin-1 receptor 3 ;
IL-1R-3 ;
IL-1R3 ;
IL-1 receptor accessory protein ;
IL-1RAcP ;
Interleukin-1 receptor 3 ;
IL-1R-3 ;
IL-1R3 ;
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Database Link:
Background:
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009],
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Function:
Function:Mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.,induction:Phorbol ester treatment causes down-regulation of isoform 1 and induction of isoform 2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in liver, skin, placenta, thymus and lung.,
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Cellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
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Tissue Expression:
Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850).
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Research Areas:
>>MAPK signaling pathway ;
>>Cytokine-cytokine receptor interaction ;
>>Th17 cell differentiation ;
>>Inflammatory mediator regulation of TRP channels
>>Cytokine-cytokine receptor interaction ;
>>Th17 cell differentiation ;
>>Inflammatory mediator regulation of TRP channels
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Signaling Pathway
Organismal Systems >> Immune system >> Th17 cell differentiation
Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
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Catalog: YN3225
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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