Synthesized peptide derived from human protein . at AA range: 490-570

ADCY2 Polyclonal Antibody detects endogenous levels of protein.

ADCY2 KIAA1060

Adenylate cyclase type 2 (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2)

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.,Function:This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.,miscellaneous:The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,tissue specificity:Expressed in brain.,

Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm .

Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.

>>Purine metabolism ;
>>Metabolic pathways ;
>>Endocrine resistance ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Oocyte meiosis ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Adrenergic signaling in cardiomyocytes ;
>>Vascular smooth muscle contraction ;
>>Apelin signaling pathway ;
>>Gap junction ;
>>Platelet activation ;
>>Circadian entrainment ;
>>Thermogenesis ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Cholinergic synapse ;
>>GABAergic synapse ;
>>Inflammatory mediator regulation of TRP channels ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Ovarian steroidogenesis ;
>>Progesterone-mediated oocyte maturation ;
>>Estrogen signaling pathway ;
>>Melanogenesis ;
>>Thyroid hormone synthesis ;
>>Oxytocin signaling pathway ;
>>Glucagon signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Aldosterone synthesis and secretion ;
>>Relaxin signaling pathway ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Salivary secretion ;
>>Gastric acid secretion ;
>>Pancreatic secretion ;
>>Bile secretion ;
>>Morphine addiction ;
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Dilated cardiomyopathy