Synthesized peptide derived from human protein . at AA range: 530-610

NAC3 Polyclonal Antibody detects endogenous levels of protein.

SLC8A3 NCX3

Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3)

This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013],

enzyme regulation:By intracellular calcium ions.,Function:Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.,similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.,similarity:Contains 2 Calx-beta domains.,tissue specificity:Isoform 2 is expressed in brain and skeletal muscle; Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle; Isoform 4 is expressed in skeletal muscle.,

Cell membrane ; Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, dendritic spine . Cell membrane, sarcolemma . Cytoplasm, sarcoplasm . Cell junction . Mitochondrion outer membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Detected at neuromuscular junctions. .

Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.

>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>Cardiac muscle contraction ;
>>Adrenergic signaling in cardiomyocytes ;
>>Apelin signaling pathway ;
>>Olfactory transduction ;
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Protein digestion and absorption ;
>>Mineral absorption ;
>>Hypertrophic cardiomyopathy ;
>>Arrhythmogenic right ventricular cardiomyopathy ;
>>Dilated cardiomyopathy