Synthesized peptide derived from human protein . at AA range: 200-280

RXRA Polyclonal Antibody detects endogenous levels of protein.

RXRA NR2B1

Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)

retinoid X receptor alpha(RXRA) Homo sapiens Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014],

Domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,Function:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer.,online information:Retinoid X receptor entry,PTM:Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with FAM120B (By similarity). Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts with SENP6. Interacts with DNTTIP2. Interacts with RNF8.,tissue specificity:Highly expressed in liver, also found in lung, kidney and heart.,

Nucleus . Cytoplasm . Mitochondrion . Localization to the nucleus is enhanced by vitamin D3 (PubMed:15509776). Nuclear localization may be enhanced by the interaction with heterodimerization partner VDR (PubMed:12145331). Translocation to the mitochondrion upon interaction with NR4A1 (PubMed:17761950, PubMed:15509776). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758). .

Expressed in lung fibroblasts (at protein level) (PubMed:30216632). Expressed in monocytes (PubMed:26463675). Highly expressed in liver, also found in kidney and brain (PubMed:24275569, PubMed:2159111, PubMed:14702039).

>>PPAR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Th17 cell differentiation ;
>>Thyroid hormone signaling pathway ;
>>Adipocytokine signaling pathway ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Non-alcoholic fatty liver disease ;
>>Bile secretion ;
>>Hepatitis C ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Thyroid cancer ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer ;
>>Gastric cancer ;
>>Lipid and atherosclerosis