Catalog: YC0028
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
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0
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Main Information
Target
Caspase-4
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, IF, ELISA
MW
43kD,22kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-4 p20 protein resulting from cleavage adjacent to Q81.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
43kD,22kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
RRID
AB_3662999
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Caspase 4. AA range:62-111
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Specificity:
Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-4 p20 protein resulting from cleavage adjacent to Q81.
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Gene Name:
CASP4 ICH2
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Protein Name:
Caspase4
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Other Name:
CASP4 ;
ICH2 ;
Caspase-4 ;
CASP-4 ;
ICE ;
rel ;
-II ;
Protease ICH-2 ;
Protease TX
ICH2 ;
Caspase-4 ;
CASP-4 ;
ICE ;
rel ;
-II ;
Protease ICH-2 ;
Protease TX
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Background:
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.,Function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit.,tissue specificity:Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.,
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Cellular Localization:
Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion . Inflammasome . Secreted . Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). .
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Tissue Expression:
Research Areas:
>>Neutrophil extracellular trap formation ;
>>NOD-like receptor signaling pathway ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection
>>NOD-like receptor signaling pathway ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection
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Signaling Pathway
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Catalog: YC0028
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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