Catalog: YM6256
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
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Collected
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Main Information
Target
CD68
Host Species
Rabbit
Reactivity
Human
Applications
IHC
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:400
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT134
Isotype
IgG, Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Endogenous
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Gene Name:
CD68
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Protein Name:
Macrosialin
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Other Name:
CD68 ;
Macrosialin ;
Gp110 ;
CD68
Macrosialin ;
Gp110 ;
CD68
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Background:
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris , promote phagocytosis , and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq , Jul 2008] ,
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Function:
Function:Could play a role in phagocytic activities of tissue macrophages , both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Bind to tissue- and organ-specific lectins or selectins , allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes , lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells. ,PTM:N- and O-glycosylated. ,similarity:Belongs to the LAMP family. ,tissue specificity:Highly expressed by blood monocytes and tissue macrophages. Also expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium , facilitating their dissemination to secondary sites. ,
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Cellular Localization:
Membrane
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Research Areas:
>>Lysosome
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Signaling Pathway
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Catalog: YM6256
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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