Catalog: YV0028
Size
Price
Status
Qty.
100mg
$7,800.00
In stock
0
50mg
$5,600.00
In stock
0
25mg
$3,600.00
In stock
0
5mg
$1,100.00
In stock
0
1mg
$300.00
In stock
0
Add to cart
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Main Information
Target
IFN α/βRα
Host Species
Rat
Reactivity
Mouse
Applications
In vivo
Detailed Information
Formulation
0.01M PBS, pH 7.4.
Purification
Protein A/G purified from cell culture supernatant.
Purity
Endotoxin level <1 EU/mg. Purity>95% as determined by SDS-PAGE.
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Concentration
Lot depended
Clonality
Monoclonal
Isotype
IgG1,kappa
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Antigen&Target Information
Gene Name:
IFNAR1
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Protein Name:
Interferon alpha/beta receptor 1
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Other Name:
IFNAR1 ;
IFNAR ;
Interferon alpha/beta receptor 1 ;
IFN-R-1 ;
IFN-alpha/beta receptor 1 ;
Cytokine receptor class-II member 1 ;
Cytokine receptor family 2 member 1 ;
CRF2-1 ;
Type I interferon receptor 1
IFNAR ;
Interferon alpha/beta receptor 1 ;
IFN-R-1 ;
IFN-alpha/beta receptor 1 ;
Cytokine receptor class-II member 1 ;
Cytokine receptor family 2 member 1 ;
CRF2-1 ;
Type I interferon receptor 1
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Background:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008],
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Function:
Function:Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.,PTM:Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 3 fibronectin type-III domains.,tissue specificity:IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R, isoform 1 is not expressed in U266R.,
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Cellular Localization:
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Late endosome . Lysosome . Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes. .
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Research Areas:
For research use only.
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Organismal Systems >> Development and regeneration >> Osteoclast differentiation
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Reference Citation({{totalcount}})
Catalog: YV0028
Size
Price
Status
Qty.
100mg
$7,800.00
In stock
0
50mg
$5,600.00
In stock
0
25mg
$3,600.00
In stock
0
5mg
$1,100.00
In stock
0
1mg
$300.00
In stock
0
Add to cart
Collected
Collect
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