The antiserum was produced against synthesized peptide derived from human LIPI. AA range:289-338

LPD lipase Polyclonal Antibody detects endogenous levels of LPD lipase protein.

LIPI

Lipase member I

LIPI ;
LPDL ;
PRED5 ;
Lipase member I ;
LIPI ;
Cancer/testis antigen 17 ;
CT17 ;
LPD lipase ;
Membrane-associated phosphatidic acid-selective phospholipase A1-beta ;
mPA-PLA1 beta

The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Disease:Defects in LIPI may be a cause of susceptibility to familial hypertrigliceridemia [MIM:145750]. Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.,enzyme regulation:Inhibited by sodium vanadate.,Function:Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,subcellular location:May associate with lipid draft.,subunit:Interacts with heparin with a high affinity.,tissue specificity:Expressed in testis. Expressed exclusively at the connecting piece of the sperm.,

[Isoform 1]: Cell membrane . Secreted . May associate with lipid draft. .; [Isoform 2]: Cell membrane . Secreted . May associate with lipid draft. .

Expressed in testis. Expressed exclusively at the connecting piece of the sperm.