Synthesized peptide derived from Fyb . at AA range: 620-700

Fyb Polyclonal Antibody detects endogenous levels of Fyb protein.

FYB

FYN-binding protein

FYB ;
SLAP130 ;
FYN-binding protein ;
Adhesion and degranulation promoting adaptor protein ;
ADAP ;
FYB-120/130 ;
p120/p130 ;
FYN-T-binding protein ;
SLAP-130 ;
SLP-76-associated phosphoprotein

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],

Function:Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.,PTM:T-cell receptor ligation leads to increased tyrosine phosphorylation.,similarity:Contains 1 SH3 domain.,subunit:Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2.,tissue specificity:Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.,

Cytoplasm . Nucleus . Cell junction . Colocalizes with TMEM47 at cell-cell contacts in podocytes. .

>>Rap1 signaling pathway ;
>>Yersinia infection