Catalog: YT0669
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
Main Information
Target
Catenin-α E/N
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
100kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Catenin-α E/N Polyclonal Antibody detects endogenous levels of Catenin-α E/N protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
100kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
Related Products
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
More→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
More→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
More→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
More→
Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Catenin-alpha1. AA range:857-906
show all
Specificity:
Catenin-α E/N Polyclonal Antibody detects endogenous levels of Catenin-α E/N protein.
show all
Gene Name:
CTNNA1/CTNNA2
show all
Protein Name:
Catenin alpha-1/2
show all
Other Name:
CTNNA1 ;
Catenin alpha-1 ;
Alpha E-catenin ;
Cadherin-associated protein ;
Renal carcinoma antigen NY-REN-13 ;
CTNNA2 ;
CAPR ;
Catenin alpha-2 ;
Alpha N-catenin ;
Alpha-catenin-related protein
Catenin alpha-1 ;
Alpha E-catenin ;
Cadherin-associated protein ;
Renal carcinoma antigen NY-REN-13 ;
CTNNA2 ;
CAPR ;
Catenin alpha-2 ;
Alpha N-catenin ;
Alpha-catenin-related protein
show all
Background:
catenin alpha 1(CTNNA1) Homo sapiens This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016],
show all
Function:
Disease:Abnormalities of alpha-catenin are involved in the process of cancer invasion and metastasis.,Function:Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.,PTM:Sumoylated.,similarity:Belongs to the vinculin/alpha-catenin family.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,subunit:Binds MLLT4 and F-actin (By similarity). Interacts directly with PSEN1 and CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21 and with JUB.,tissue specificity:Expressed ubiquitously in normal tissues.,
show all
Cellular Localization:
[Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.; [Isoform 3]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
show all
Tissue Expression:
Research Areas:
>>Hippo signaling pathway ;
>>Adherens junction ;
>>Leukocyte transendothelial migration ;
>>Bacterial invasion of epithelial cells ;
>>Pathways in cancer ;
>>Endometrial cancer ;
>>Gastric cancer ;
>>Arrhythmogenic right ventricular cardiomyopathy
>>Adherens junction ;
>>Leukocyte transendothelial migration ;
>>Bacterial invasion of epithelial cells ;
>>Pathways in cancer ;
>>Endometrial cancer ;
>>Gastric cancer ;
>>Arrhythmogenic right ventricular cardiomyopathy
show all
Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Adherens junction
Organismal Systems >> Immune system >> Leukocyte transendothelial migration
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Endometrial cancer
Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Reference Citation({{totalcount}})
Catalog: YT0669
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}