Catalog: YP1016
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
Catenin-α1 Phospho Ser641
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
MW
100kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-Catenin-α1 (S641) Polyclonal Antibody detects endogenous levels of Catenin-α1 protein only when phosphorylated at S641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DDsDF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
100kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Catenin-alpha1 around the phosphorylation site of Ser641. AA range:607-656
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Specificity:
Phospho-Catenin-α1 (S641) Polyclonal Antibody detects endogenous levels of Catenin-α1 protein only when phosphorylated at S641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DDsDF
show all
Gene Name:
CTNNA1
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Protein Name:
Catenin alpha-1
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Other Name:
CTNNA1 ;
Catenin alpha-1 ;
Alpha E-catenin ;
Cadherin-associated protein ;
Renal carcinoma antigen NY-REN-13
Catenin alpha-1 ;
Alpha E-catenin ;
Cadherin-associated protein ;
Renal carcinoma antigen NY-REN-13
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Background:
catenin alpha 1(CTNNA1) Homo sapiens This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016],
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Function:
Disease:Abnormalities of alpha-catenin are involved in the process of cancer invasion and metastasis.,Function:Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.,PTM:Sumoylated.,similarity:Belongs to the vinculin/alpha-catenin family.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,subunit:Binds MLLT4 and F-actin (By similarity). Interacts directly with PSEN1 and CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21 and with JUB.,tissue specificity:Expressed ubiquitously in normal tissues.,
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Cellular Localization:
[Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.; [Isoform 3]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
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Tissue Expression:
Research Areas:
>>Hippo signaling pathway ;
>>Adherens junction ;
>>Leukocyte transendothelial migration ;
>>Bacterial invasion of epithelial cells ;
>>Pathways in cancer ;
>>Endometrial cancer ;
>>Gastric cancer ;
>>Arrhythmogenic right ventricular cardiomyopathy
>>Adherens junction ;
>>Leukocyte transendothelial migration ;
>>Bacterial invasion of epithelial cells ;
>>Pathways in cancer ;
>>Endometrial cancer ;
>>Gastric cancer ;
>>Arrhythmogenic right ventricular cardiomyopathy
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Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Adherens junction
Organismal Systems >> Immune system >> Leukocyte transendothelial migration
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Endometrial cancer
Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
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Catalog: YP1016
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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