The antiserum was produced against synthesized peptide derived from human IL-1Ralpha/CD121alpha around the phosphorylation site of Tyr496. AA range:471-520

Phospho-IL-1RI (Y496) Polyclonal Antibody detects endogenous levels of IL-1RI protein only when phosphorylated at Y496.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QDyEK

IL1R1

Interleukin-1 receptor type 1

IL1R1 ;
IL1R ;
IL1RA ;
IL1RT1 ;
Interleukin-1 receptor type 1 ;
IL-1R-1 ;
IL-1RT-1 ;
IL-1RT1 ;
CD121 antigen-like family member A ;
Interleukin-1 receptor alpha ;
IL-1R-alpha ;
Interleukin-1 receptor type I ;
p80 ;
CD antigen CD121a

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013],

Function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP.,

Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted .

Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.

>>MAPK signaling pathway ;
>>Cytokine-cytokine receptor interaction ;
>>NF-kappa B signaling pathway ;
>>Osteoclast differentiation ;
>>Hematopoietic cell lineage ;
>>Th17 cell differentiation ;
>>Inflammatory mediator regulation of TRP channels ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Amoebiasis ;
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Fluid shear stress and atherosclerosis