Catalog: YN5673
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
ATG4B
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF
MW
44kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:50-300; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
The antibody detects endogenous ATG4b protein
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
44kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Recombinant Protein of ATG4b
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Specificity:
The antibody detects endogenous ATG4b protein
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Gene Name:
ATG4B APG4B AUTL1 KIAA0943
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Protein Name:
Cysteine protease ATG4B
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Other Name:
ATG4B ;
APG4B ;
AUTL1 ;
KIAA0943 ;
Cysteine protease ATG4B ;
AUT-like 1 cysteine endopeptidase ;
Autophagin-1 ;
Autophagy-related cysteine endopeptidase 1 ;
Autophagy-related protein 4 homolog B ;
hAPG4B
APG4B ;
AUTL1 ;
KIAA0943 ;
Cysteine protease ATG4B ;
AUT-like 1 cysteine endopeptidase ;
Autophagin-1 ;
Autophagy-related cysteine endopeptidase 1 ;
Autophagy-related protein 4 homolog B ;
hAPG4B
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Background:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
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Function:
enzyme regulation:Inhibited by N-ethylmaleimide.,Function:Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.,similarity:Belongs to the peptidase C54 family.,tissue specificity:Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.,
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Cellular Localization:
Cytoplasm . Cytoplasm, cytosol . Cytoplasmic vesicle, autophagosome . Endoplasmic reticulum . Mitochondrion . Mainly localizes to the cytoplasm, including cytosol (PubMed:29165041). A samll potion localizes to mitochondria; phosphorylation at Ser-34 promotes localization to mitochondria (PubMed:29165041). .
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Tissue Expression:
Research Areas:
>>Autophagy - other ;
>>Autophagy - animal
>>Autophagy - animal
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YN5673
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
Add to cart
Collected
Collect
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