SKI proto-oncogene(SKI) Homo sapiens This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009],
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Function:
Function:May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage.,similarity:Belongs to the SKI family.,subunit:Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3.,