Synthesized peptide derived from human protein . at AA range: 190-270

AXIN1 Polyclonal Antibody detects endogenous levels of protein.

AXIN1 AXIN

Axin-1 (Axis inhibition protein 1) (hAxin)

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

Disease:Defects in AXIN1 are involved in hepatocellular carcinoma (HCC) [MIM:114550].,Disease:Hypermethylation of the AXIN1 promoter may be associated with caudal duplication anomaly [MIM:607864]. Caudal duplication anomaly is characterized by the occurrence of duplications of different organs in the caudal region.,Function:Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of beta-catenin and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Wild-type axin 1 can induce apoptosis in hepatocellular and colorectal cancer cells. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.,PTM:Probably phosphorylated by GSK3B and dephosphorylated by PP2A.,similarity:Contains 1 DIX domain.,similarity:Contains 1 RGS domain.,subunit:Homodimer (By similarity). Interacts with TP53 and HIPK2. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin. Ternary complex. Also binds to plakoglobin (gamma-catenin), APC, DVL and PP2A. Interacts with SMAD6, SMAD7 and RNF111. Interacts with DIXDC1; prevents interaction with MAP3K1. Interacts with MAP3K4, MDFI and MDFIC. Interacts with ANKRD6. Interacts with AIDA.,tissue specificity:Ubiquitously expressed.,

Cytoplasm . Nucleus . Membrane . Cell membrane . MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684). .

Ubiquitously expressed.

>>Wnt signaling pathway ;
>>Hippo signaling pathway ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>Cushing syndrome ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Human papillomavirus infection ;
>>Pathways in cancer ;
>>Colorectal cancer ;
>>Endometrial cancer ;
>>Basal cell carcinoma ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer