Catalog: YM9527
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
PKD2
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
97kD (Calculated)
115kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
97kD
MW(Observed)
115kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT1685R
Isotype
IgG,Kappa
Related Products
Primary Antibodies
PKD2 Rabbit pAb
YT3773
More→
Primary Antibodies
PKD2 (Phospho Ser876) Rabbit pAb
YP0341
More→
ELISA Kits
Total PKD2 Cell-Based Colorimetric ELISA Kit
KA4244C
More→
ELISA Kits
PKD2 (Phospho Ser876) Cell-Based Colorimetric ELISA Kit
KA1415C
More→
Antigen&Target Information
Specificity:
Endogenous
show all
Gene Name:
PRKD2
show all
Protein Name:
Serine/threonine-protein kinase D2
show all
Other Name:
PRKD2 ;
PKD2 ;
HSPC187 ;
Serine/threonine-protein kinase D2 ;
nPKC-D2
PKD2 ;
HSPC187 ;
Serine/threonine-protein kinase D2 ;
nPKC-D2
show all
Database Link:
Background:
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
show all
Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by diacylglycerol and phorbol esters.,Function:Calcium-independent, phospholipid-dependent, serine- and threonine-specific protein kinase.,PTM:Autophosphorylated. Phorbol esters stimulates autophosphorylation. Phosphorylation of Ser-876 correlates with the activation status of the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,tissue specificity:Widely expressed.,
show all
Cellular Localization:
Cytoplasm . Cell membrane . Nucleus . Golgi apparatus, trans-Golgi network . Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. .
show all
Tissue Expression:
show all
Research Areas:
>>Rap1 signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
>>Aldosterone synthesis and secretion ;
>>Chemical carcinogenesis - reactive oxygen species
show all
Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM9527
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}