R

IL-2 (PT1458R) PT™ Rabbit mAb

-YM9300

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Catalog: YM9300
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$340.00
3 weeks

0

40μL
$190.00
3 weeks

0

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Collected

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Main Information
Target

IL-2

Host Species

Rabbit

Reactivity

Human

Applications

WB, IF, IP, ELISA

MW

18kD (Calculated)

14kD (Observed)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
18kD
MW(Observed)
14kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT1458R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
IL2
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Protein Name:
Interleukin-2
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Other Name:
IL2 ;
Interleukin-2 ;
IL-2 ;
T-cell growth factor ;
TCGF ;
Aldesleukin
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Database Link:
Organism Gene ID SwissProt
Human 3558; P60568;
Mouse P04351;
Rat 116562; P17108;
Background:
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008],
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Function:
Disease:A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.,Function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.,online information:Interleukin-2 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.,similarity:Belongs to the IL-2 family.,
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Cellular Localization:
Secreted.
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Tissue Expression:
Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>PI3K-Akt signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>JAK-STAT signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>T cell receptor signaling pathway ;
>>Intestinal immune network for IgA production ;
>>Type I diabetes mellitus ;
>>Yersinia infection ;
>>Chagas disease ;
>>Measles ;
>>Human T-cell leukemia virus 1 infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer ;
>>Autoimmune thyroid disease ;
>>Inflammatory bowel disease ;
>>Allograft rejection ;
>>Graft-versus-host disease
show all
Catalog: YM9300
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$340.00
3 weeks

0

40μL
$190.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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