Endogenous

LGALS1

Galectin-1

LGALS1 ;
Galectin-1 ;
Gal-1 ;
14 kDa laminin-binding protein ;
HLBP14 ;
14 kDa lectin ;
Beta-galactoside-binding lectin L-14-I ;
Galaptin ;
HBL ;
HPL ;
Lactose-binding lectin 1 ;
Lectin galactoside-binding soluble 1 ;
Putative MAPK-activating protein P

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008],

Function:May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.,online information:Galectin-1,similarity:Contains 1 galectin domain.,subunit:Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45.,tissue specificity:Cardiac, smooth, and skeletal muscle, neurons, thymus, kidney, placenta and hematopoietic cells.,

Secreted, extracellular space, extracellular matrix . Cytoplasm . Secreted . Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. .