Catalog: YM8893
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
SLFN12
Host Species
Rabbit
Reactivity
Human
Applications
WB, FC
MW
64kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:1000-5000; FC 1:100-300
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Observed)
64kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0798R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
SLFN12
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Protein Name:
Ribonuclease SLFN12;Schlafen family member 12;
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Other Name:
SLFN12 ;
Ribonuclease SLFN12 ;
Schlafen family member 12 ;
Ribonuclease SLFN12 ;
Schlafen family member 12 ;
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Background:
Enables RNA nuclease activity and ribosome binding activity. Involved in apoptotic signaling pathway and rRNA catabolic process. Part of cytosol and nucleus. [provided by Alliance of Genome Resources, Feb 2025]
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Function:
Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34272366, PubMed:34707099, PubMed:35104454). May play a role in cell differentiation (PubMed:30045019). {ECO:0000269|PubMed:30045019, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34272366, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:35104454}.
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Cellular Localization:
Nucleus. Cytoplasm, cytosol.
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Reference Citation({{totalcount}})
Catalog: YM8893
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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