Catalog: YM8877
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
AurC
Host Species
Rabbit
Reactivity
Human
Applications
WB, IF, ELISA
MW
36kD (Calculated)
36kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
36kD
MW(Observed)
36kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT1145R
Isotype
IgG,Kappa
RRID
AB_3711181
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
AURKC
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Protein Name:
Serine/threonine-protein kinase 13/Aurora kinase C
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Other Name:
AIE2,AIK3,AIRK3,ARK3,STK13,Aurora kinase C,Aurora 3,Aurora/IPL1 related kinase 3,ARK 3,Aurora related kinase 3,Serine/threonine protein kinase 13,Aurora/IPL1related kinase 3,Aurorarelated kinase 3,Serine/threonineprotein kinase 13,Serine/threonineprotein kinase auroraC,
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Background:
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
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Function:
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
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Cellular Localization:
Nucleus,Chromosome,Chromosome, centromere,Cytoplasm, cytoskeleton, spindle,Note: Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.
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Reference Citation({{totalcount}})
Catalog: YM8877
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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