Catalog: YM8582
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
RB11A,Rab11B
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
24kD (Calculated)
24kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:1000-1:5000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
24kD
MW(Observed)
24kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0823R
Isotype
IgG, Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Endogenous
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Gene Name:
RAB11A,RAB11B
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Protein Name:
Ras-related protein Rab-11A,Rab-11,YL8,Ras-related protein Rab-11B
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Other Name:
RAB11A ;
Ras-related protein Rab-11A ;
RAB11B ;
YPT3 ;
Ras-related protein Rab-11B ;
GTP-binding protein YPT3 ;
Ras-related protein Rab-11A ;
RAB11B ;
YPT3 ;
Ras-related protein Rab-11B ;
GTP-binding protein YPT3 ;
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Database Link:
Background:
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways , and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , May 2011]
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Function:
Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP , RAB8A , the exocyst complex , PARD3 , PRKCI , ANXA2 , CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS) , apical surface formation and lumenogenesis (By similarity) . Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.
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Cellular Localization:
Cell membrane ; Lipid-anchor . Recycling endosome membrane ; Lipid-anchor . Cleavage furrow . Cytoplasmic vesicle , phagosome . Cytoplasmic vesicle membrane . Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279) . Localizes to the cleavage furrow (PubMed:15601896) . Colocalizes with PARD3 , PRKCI , EXOC5 , OCLN , PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297) . Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211) . Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle , secretory vesicle , synaptic vesicle membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle , phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Recruited to phagosomes containing S.aureus.
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Tissue Expression:
Research Areas:
>>Endocytosis ;
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Vasopressin-regulated water reabsorption ;
>>Pancreatic secretion ;
>>Influenza A
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Vasopressin-regulated water reabsorption ;
>>Pancreatic secretion ;
>>Influenza A
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM8582
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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