Endogenous

GSK3B

Glycogen synthase kinase-3 beta

GSK3B ;
Glycogen synthase kinase-3 beta ;
GSK-3 beta ;
Serine/threonine-protein kinase GSK3B

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],

Catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,Function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.,

Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .

>>EGFR tyrosine kinase inhibitor resistance ;
>>ErbB signaling pathway ;
>>Chemokine signaling pathway ;
>>Cell cycle ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Wnt signaling pathway ;
>>Hedgehog signaling pathway ;
>>Axon guidance ;
>>Hippo signaling pathway ;
>>Focal adhesion ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>IL-17 signaling pathway ;
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway ;
>>Neurotrophin signaling pathway ;
>>Dopaminergic synapse ;
>>Insulin signaling pathway ;
>>Melanogenesis ;
>>Prolactin signaling pathway ;
>>Thyroid hormone signaling pathway ;
>>Insulin resistance ;
>>Non-alcoholic fatty liver disease ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Alcoholic liver disease ;
>>Alzheimer disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis ;
>>Yersinia infection ;
>>Hepatitis C ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Pathways in cancer ;
>>Colorectal cancer ;
>>Endometrial cancer ;
>>Prostate cancer ;
>>Basal cell carcinoma ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis