Cleaved N-terminal GSDMD (PT0680R) PT™ Rabbit mAb
-YM8489
Catalog: YM8489
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
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0
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Main Information
Target
GSDMD
Host Species
Rabbit
Reactivity
Human
Applications
WB, IF, ELISA
MW
53kD (Calculated)
35kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
This antibody detects endogenous levels of Cleaved N-terminal GSDMD.
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
53kD
MW(Observed)
35kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0680R
Isotype
IgG,Kappa
RRID
AB_3717472
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Antigen&Target Information
Specificity:
This antibody detects endogenous levels of Cleaved N-terminal GSDMD.
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Gene Name:
GSDMD
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Protein Name:
Gasdermin domain-containing protein 1,Gasdermin-D,GSDMD,GSDMD-CT,GSDMD-NT,GSDMD_HUMAN
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Database Link:
| Organism | Gene ID | SwissProt |
|---|---|---|
| Human | P57764; |
Function:
Cleavage at Asp-275 by CASP1 (mature and uncleaved precursor forms), CASP4, CASP5 or CASP8 relieves autoinhibition and is sufficient to initiate pyroptosis (PubMed:26375003, PubMed:29898893, PubMed:32109412). Cleavage by CASP1 and CASP4 is not strictly dependent on the consensus cleavage site on GSDMD but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Cleavage by CASP8 takes place following inactivation of MAP3K7/TAK1 by Yersinia toxin YopJ (By similarity). Cleavage at Asp-87 by CASP3 or CAPS7 inactivates the ability to mediate pyroptosis (PubMed:28392147, PubMed:28045099).
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Cellular Localization:
[Gasdermin-D]: Cytoplasm, cytosol . Inflammasome . In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor. .; [Gasdermin-D, N-terminal]: Cell membrane ; Multi-pass membrane protein . Secreted . Released in the extracellular milieu following pyroptosis. .; [Gasdermin-D, C-terminal]: Cytoplasm, cytosol .
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Tissue Expression:
Research Areas:
>>Neutrophil extracellular trap formation ;
>>NOD-like receptor signaling pathway ;
>>Salmonella infection
>>NOD-like receptor signaling pathway ;
>>Salmonella infection
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Reference Citation({{totalcount}})
Catalog: YM8489
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
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