Endogenous

HSP90AB1

Heat shock protein HSP 90-beta

HSP90AB1 ;
HSP90B ;
HSPC2 ;
HSPCB ;
Heat shock protein HSP 90-beta ;
HSP 90 ;
Heat shock 84 kDa ;
HSP 84 ;
HSP84

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012],

Function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer.,

Cytoplasm, Nuclear

>>Protein processing in endoplasmic reticulum ;
>>PI3K-Akt signaling pathway ;
>>Necroptosis ;
>>Antigen processing and presentation ;
>>NOD-like receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>Th17 cell differentiation ;
>>Progesterone-mediated oocyte maturation ;
>>Estrogen signaling pathway ;
>>Salmonella infection ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Prostate cancer ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis