Catalog: YM3115
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
Add to cart
Collected
Collect
Conjugated antibody
α Tubulin (8F11) Mouse mAb (AbFluor 350)
α Tubulin (8F11) Mouse mAb (AbFluor 405)
α Tubulin (8F11) Mouse mAb (AbFluor 488)
α Tubulin (8F11) Mouse mAb (AbFluor 555)
α Tubulin (8F11) Mouse mAb (AbFluor 594)
α Tubulin (8F11) Mouse mAb (AbFluor 647)
α Tubulin (8F11) Mouse mAb (AbFluor 680)
α Tubulin (8F11) Mouse mAb (Biotin)
α Tubulin (8F11) Mouse mAb (Cy3)
α Tubulin (8F11) Mouse mAb (Cy5)
α Tubulin (8F11) Mouse mAb (FITC)
α Tubulin (8F11) Mouse mAb (HRP)
Main Information
Target
α Tubulin
Host Species
Mouse
Reactivity
Zebrafish
Applications
WB
MW
52kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-10000
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Specificity
The antibody detects Zebrafish endogenous α-tubulin protein.
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Observed)
52kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
14B11
RRID
AB_3696731
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Antigen&Target Information
Immunogen:
Recombinant Protein of Tubulin alpha-1A chain
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Specificity:
The antibody detects Zebrafish endogenous α-tubulin protein.
show all
Gene Name:
TUBA1A
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Protein Name:
Tubulin alpha-1A chain
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Other Name:
TUBA1A
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Database Link:
Background:
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
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Function:
Disease:Defects in TUBA1A are the cause of lissencephaly type 3 (LIS3) [MIM:611603]. LIS is characterized by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of surface convolutions. It is often associated with psychomotor retardation and seizures. LIS3 features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem.,Function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,PTM:Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,tissue specificity:Expressed at a high level in fetal brain.,
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Cellular Localization:
Cytoplasm, cytoskeleton.
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Tissue Expression:
Research Areas:
>>Phagosome ;
>>Gap junction ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection
>>Gap junction ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection
show all
Signaling Pathway
Cellular Processes >> Transport and catabolism >> Phagosome
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cellular community - eukaryotes >> Tight junction
Cellular Processes >> Cellular community - eukaryotes >> Gap junction
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Parkinson disease
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Huntington disease
Human Diseases >> Neurodegenerative disease >> Prion disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Reference Citation({{totalcount}})
Catalog: YM3115
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
Add to cart
Collected
Collect
Conjugated antibody
α Tubulin (8F11) Mouse mAb (AbFluor 350)
α Tubulin (8F11) Mouse mAb (AbFluor 405)
α Tubulin (8F11) Mouse mAb (AbFluor 488)
α Tubulin (8F11) Mouse mAb (AbFluor 555)
α Tubulin (8F11) Mouse mAb (AbFluor 594)
α Tubulin (8F11) Mouse mAb (AbFluor 647)
α Tubulin (8F11) Mouse mAb (AbFluor 680)
α Tubulin (8F11) Mouse mAb (Biotin)
α Tubulin (8F11) Mouse mAb (Cy3)
α Tubulin (8F11) Mouse mAb (Cy5)
α Tubulin (8F11) Mouse mAb (FITC)
α Tubulin (8F11) Mouse mAb (HRP)
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