Catalog: YM2222
Size
Price
Status
Qty.
200μL
$650.00
1 weeks
0
100μL
$380.00
1 weeks
0
Add to cart
Collected
Collect
Main Information
Target
CD19
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, IF, IP, ELISA
MW
61kD (Calculated)
110kD (Observed)
Conjugate/Modification
AbFluor 488
Unmodified
Detailed Information
Recommended Dilution Ratio
IF 1:100-500; ELISA 1:5000-20000;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
61kD
MW(Observed)
110kD
Modification
Unmodified
Conjugate
AbFluor 488
Clonality
Monoclonal
Clone Number
PT0089R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
CD19
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Protein Name:
B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)
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Background:
CD19 molecule(CD19) Homo sapiens Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],
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Function:
Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge .
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Cellular Localization:
Membranous
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Signaling Pathway
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Catalog: YM2222
Size
Price
Status
Qty.
200μL
$650.00
1 weeks
0
100μL
$380.00
1 weeks
0
Add to cart
Collected
Collect
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