Catalog: YM1343
Size
Price
Status
Qty.
200μL
$450.00
3 weeks

0

100μL
$280.00
3 weeks

0

40μL
$160.00
3 weeks

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Main Information
Target

cIAP2

Host Species

Mouse

Reactivity

Human, Monkey

Applications

WB

MW

72kD (Observed)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
WB 1:1000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of c-IAP2 and does not cross-react with related proteins.
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Observed)
72kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
12E2
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Antigen&Target Information
Immunogen:
Purified recombinant human c-IAP2 protein fragments expressed in E.coli
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Specificity:
This antibody detects endogenous levels of c-IAP2 and does not cross-react with related proteins.
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Gene Name:
birc3
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Other Name:
AIP 1 ;
AIP1 ;
API 2 ;
API2 ;
API2 ;
Apoptosis inhibitor 2 ;
Baculoviral IAP repeat containing 3 ;
Baculoviral IAP repeat containing protein 3 ;
Baculoviral IAP repeat-containing protein 3 ;
BIRC 3 ;
BIRC3 ;
BIRC3 ;
BIRC3_HUMAN ;
C IAP2 ;
C-IAP2 ;
CIAP 2 ;
CIAP 2 ;
CIAP2 ;
HAIP 1 ;
HAIP1 ;
HAIP1 ;
HIAP 1 ;
HIAP-1 ;
HIAP1 ;
IAP homolog C ;
IAP-1 ;
Inhibitor of apoptosis protein 1 ;
Inhibitor of apoptosis protein 1 ;
MALT 2 ;
MALT2 ;
Mammalian IAP homolog C ;
MIHC ;
MIHC ;
RING finger protein 49 ;
RNF49 ;
TNFR2 TRAF signaling complex protein 1 ;
TNFR2 TRAF signalling complex protein ;
TNFR2-TRAF-signaling complex protein 1.
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Database Link:
Organism Gene ID SwissProt
Human 330; Q13489;
Mouse O08863;
Background:
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011],
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Function:
Disease:A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,Function:Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).,similarity:Belongs to the IAP family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.,tissue specificity:Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.,
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Cellular Localization:
Cytoplasm . Nucleus .
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Research Areas:
>>Platinum drug resistance ;
>>NF-kappa B signaling pathway ;
>>Ubiquitin mediated proteolysis ;
>>Apoptosis ;
>>Apoptosis - multiple species ;
>>Necroptosis ;
>>Hippo signaling pathway ;
>>Focal adhesion ;
>>NOD-like receptor signaling pathway ;
>>TNF signaling pathway ;
>>Salmonella infection ;
>>Toxoplasmosis ;
>>Herpes simplex virus 1 infection ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Small cell lung cancer
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Catalog: YM1343
Size
Price
Status
Qty.
200μL
$450.00
3 weeks

0

100μL
$280.00
3 weeks

0

40μL
$160.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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