Catalog: YC0059
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
MMP-10
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, ELISA
MW
43kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Cleaved-MMP-10 (F99) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-10 protein resulting from cleavage adjacent to F99.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
43kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human MMP10. AA range:80-129
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Specificity:
Cleaved-MMP-10 (F99) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-10 protein resulting from cleavage adjacent to F99.
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Gene Name:
MMP10
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Protein Name:
Stromelysin-2
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Other Name:
MMP10 ;
STMY2 ;
Stromelysin-2 ;
SL-2 ;
Matrix metalloproteinase-10 ;
MMP-10 ;
Transin-2
STMY2 ;
Stromelysin-2 ;
SL-2 ;
Matrix metalloproteinase-10 ;
MMP-10 ;
Transin-2
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Background:
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016],
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Function:
Catalytic activity:Similar to stromelysin 1, but action on collagen types III, IV and V is weak.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Calcium.,Domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,Function:Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,
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Cellular Localization:
Secreted, extracellular space, extracellular matrix .
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Tissue Expression:
Coronary artery,Ovary,
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Reference Citation({{totalcount}})
Catalog: YC0059
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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