Catalog: YM4457
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
IL-8RA
Host Species
Mouse
Reactivity
Human
Applications
WB
MW
147kD (Calculated)
200kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:500
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A/G affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
147kD
MW(Observed)
200kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PTR1483
Isotype
Mouse IgG2b/Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Endogenous
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Gene Name:
CXCR1 CMKAR1 IL8RA
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Protein Name:
C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
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Other Name:
C-X-C chemokine receptor type 1 ;
CXC-R1 ;
CXCR-1 ;
CDw128a ;
High affinity interleukin-8 receptor A ;
IL-8R A ;
IL-8 receptor type 1 ;
CD antigen CD181 ;
CXC-R1 ;
CXCR-1 ;
CDw128a ;
High affinity interleukin-8 receptor A ;
IL-8R A ;
IL-8 receptor type 1 ;
CD antigen CD181 ;
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Background:
C-X-C motif chemokine receptor 1 (CXCR1) Homo sapiens The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8) . It binds to IL8 with high affinity , and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene , IL8RB , a gene encoding another high affinity IL8 receptor , as well as IL8RBP , a pseudogene of IL8RB , form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq , Jul 2008] ,
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Function:
Function:Receptor to interleukin-8 , which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. ,online information:CXC chemokine receptors entry ,similarity:Belongs to the G-protein coupled receptor 1 family. ,
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Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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Tissue Expression:
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Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Epithelial cell signaling in Helicobacter pylori infection
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Epithelial cell signaling in Helicobacter pylori infection
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Signaling Pathway
Organismal Systems >> Immune system >> Chemokine signaling pathway
Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Reference Citation({{totalcount}})
Catalog: YM4457
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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