Catalog: YT2916
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$150.00
3 weeks
0
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Main Information
Target
mtTFA
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Bovine
Applications
WB, IHC, IF, ELISA
MW
22kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
mtTFA Polyclonal Antibody detects endogenous levels of mtTFA protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
22kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human TFAM. AA range:131-180
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Specificity:
mtTFA Polyclonal Antibody detects endogenous levels of mtTFA protein.
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Gene Name:
TFAM
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Protein Name:
Transcription factor A mitochondrial
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Other Name:
TFAM ;
TCF6 ;
TCF6L2 ;
Transcription factor A ;
mitochondrial ;
mtTFA ;
Mitochondrial transcription factor 1 ;
MtTF1 ;
Transcription factor 6 ;
TCF-6 ;
Transcription factor 6-like 2
TCF6 ;
TCF6L2 ;
Transcription factor A ;
mitochondrial ;
mtTFA ;
Mitochondrial transcription factor 1 ;
MtTF1 ;
Transcription factor 6 ;
TCF-6 ;
Transcription factor 6-like 2
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Background:
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6 , 7 , and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Aug 2012] ,
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Function:
Function:Involved in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. ,similarity:Contains 2 HMG box DNA-binding domains. ,subunit:Interacts with TFB1M and TFB2M. ,
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Cellular Localization:
Mitochondrion . Mitochondrion matrix , mitochondrion nucleoid .
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Tissue Expression:
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Research Areas:
>>Apelin signaling pathway ;
>>Huntington disease
>>Huntington disease
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT2916
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$150.00
3 weeks
0
Add to cart
Collected
Collect
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