The antiserum was produced against synthesized peptide derived from human JAK1. AA range:988-1037

JAK1 Polyclonal Antibody detects endogenous levels of JAK1 protein.

JAK1

Tyrosine-protein kinase JAK1

JAK1 ;
JAK1A ;
JAK1B ;
Tyrosine-protein kinase JAK1 ;
Janus kinase 1 ;
JAK-1

This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Mar 2016] ,

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity) , while the presence of slight differences suggest a different role for domain 1. ,Domain:The FERM domain mediates interaction with JAKMIP1. ,Function:Tyrosine kinase of the non-receptor type , involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL) -2 receptor. ,sequence Caution:Translation N-terminally extended. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. ,similarity:Contains 1 FERM domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH2 domain. ,subcellular location:Wholly intracellular , possibly membrane associated. ,subunit:Interacts with IL31RA , JAKMIP1 and SHB. ,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. ,

Endomembrane system; Peripheral membrane protein. Wholly intracellular , possibly membrane associated.

>>EGFR tyrosine kinase inhibitor resistance ;
>>PI3K-Akt signaling pathway ;
>>Necroptosis ;
>>Osteoclast differentiation ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>NOD-like receptor signaling pathway ;
>>JAK-STAT signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Leishmaniasis ;
>>Toxoplasmosis ;
>>Tuberculosis ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Pancreatic cancer ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer