Catalog: YT1190
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
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Main Information
Target
CYP19A1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
53kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
CYP19A1 Polyclonal Antibody detects endogenous levels of CYP19A1 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
53kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
RRID
AB_2864736
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 19A1. AA range:221-270
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Specificity:
CYP19A1 Polyclonal Antibody detects endogenous levels of CYP19A1 protein.
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Gene Name:
CYP19A1
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Protein Name:
Cytochrome P450 19A1
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Other Name:
CYP19A1 ;
ARO1 ;
CYAR ;
CYP19 ;
Cytochrome P450 19A1 ;
Aromatase ;
CYPXIX ;
Cytochrome P-450AROM ;
Estrogen synthase
ARO1 ;
CYAR ;
CYP19 ;
Cytochrome P450 19A1 ;
Aromatase ;
CYPXIX ;
Cytochrome P-450AROM ;
Estrogen synthase
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Background:
cytochrome P450 family 19 subfamily A member 1 (CYP19A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol , steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq , May 2014] ,
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Function:
Catalytic activity:RH + reduced flavoprotein + O (2) = ROH + oxidized flavoprotein + H (2) O. ,cofactor:Heme group. ,Disease:Defects in CYP19A1 are a cause of familial gynecomastia [MIM:139300]. This is characterized by an estrogen excess due to an increased aromatase activity. ,Disease:Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus , pregnant women exhibit a hirsutism , which spontaneously resolves after post-partum. At birth , female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females , manifestations include delay of puberty , breast hypoplasia and primary amenorrhoea with multicystic ovaries. ,Function:Catalyzes the formation of aromatic C18 estrogens from C19 androgens. ,online information:Aromatase entry ,similarity:Belongs to the cytochrome P450 family. ,tissue specificity:Brain , placenta and gonads. ,
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Cellular Localization:
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .
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Tissue Expression:
Research Areas:
>>Steroid hormone biosynthesis ;
>>Metabolic pathways ;
>>Ovarian steroidogenesis
>>Metabolic pathways ;
>>Ovarian steroidogenesis
show all
Reference Citation({{totalcount}})
Catalog: YT1190
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
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