The specific immunogen used to produce this antibody is proprietary information.

Endogenous

CCR6

C-C chemokine receptor type 6

CCR6 ;
CKRL3 ;
CMKBR6 ;
GPR29 ;
STRL22 ;
C-C chemokine receptor type 6 ;
C-C CKR-6 ;
CC-CKR-6 ;
CCR-6 ;
Chemokine receptor-like 3 ;
CKR-L3 ;
DRY6 ;
G-protein coupled receptor 29 ;
GPR-CY4 ;
GPRCY4 ;
LARC receptor ;
CD196

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008],

Caution:It is uncertain whether Met-1 or Met-6 is the initiator.,Domain:Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.,Function:Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.,Function:Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis.,induction:By interleukin-2.,online information:CC chemokine receptors entry,similarity:Belongs to the cyclin family. Cyclin L subfamily.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CDC2L1 or CDC2L2, SFRS2, SFRS7 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II.,tissue specificity:Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.,tissue specificity:Ubiquitously expressed, with a higher expression level observed in ovary, heart, liver and pancreas.,

Cell membrane ; Multi-pass membrane protein . Cell surface .

>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway