Catalog: YM8372
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
ATP-citrate synthase
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
121kD (Calculated)
121kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:2000-1:10000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
121kD
MW(Observed)
121kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0552R
Isotype
IgG, Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Endogenous
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Gene Name:
ACLY
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Protein Name:
ATP-citrate synthase
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Other Name:
ACLY ;
ATP-citrate synthase ;
ATP-citrate ;
pro-S-) -lyase ;
ACL ;
Citrate cleavage enzyme
ATP-citrate synthase ;
ATP-citrate ;
pro-S-) -lyase ;
ACL ;
Citrate cleavage enzyme
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Database Link:
Background:
ATP citrate lyase (ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440 ,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product , acetyl-CoA , serves several important biosynthetic pathways , including lipogenesis and cholesterogenesis. In nervous tissue , ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq , Dec 2014] ,
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Function:
Catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. ,Function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. ,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. ,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. ,subunit:Homotetramer. ,
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Cellular Localization:
Cytoplasm
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Tissue Expression:
Research Areas:
>>Citrate cycle (TCA cycle) ;
>>Metabolic pathways
>>Metabolic pathways
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Reference Citation({{totalcount}})
Catalog: YM8372
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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