Catalog: YT2452
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$150.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
KChIP1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
MW
27kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
KChIP1 Polyclonal Antibody detects endogenous levels of KChIP1 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
27kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human KCIP1. AA range:1-50
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Specificity:
KChIP1 Polyclonal Antibody detects endogenous levels of KChIP1 protein.
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Gene Name:
KCNIP1
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Protein Name:
Kv channel-interacting protein 1
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Other Name:
KCNIP1 ;
KCHIP1 ;
VABP ;
Kv channel-interacting protein 1 ;
KChIP1 ;
A-type potassium channel modulatory protein 1 ;
Potassium channel-interacting protein 1 ;
Vesicle APC-binding protein
KCHIP1 ;
VABP ;
Kv channel-interacting protein 1 ;
KChIP1 ;
A-type potassium channel modulatory protein 1 ;
Potassium channel-interacting protein 1 ;
Vesicle APC-binding protein
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Database Link:
Background:
This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs) , which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents , and hence neuronal membrane excitability , in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq , May 2013] ,
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Function:
Function:Regulatory subunit of Kv4/D (Shal) -type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density , inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro , modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface. ,similarity:Belongs to the recoverin family. ,similarity:Contains 4 EF-hand domains. ,subunit:Component of heteromultimeric potassium channels. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1 , KCNIP2 isoform 3 and KCND2. Can self-associate to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner. Interacts with Naja atra venom CTX3. ,tissue specificity:Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver , pancreas , skeletal muscle , small intestine and testis. Isoform 2 is also expressed in lung , pancreas , leukocytes , prostate and thymus. ,
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Cellular Localization:
Cell membrane ; Peripheral membrane protein . Cytoplasm . Cell projection , dendrite .
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Reference Citation({{totalcount}})
Catalog: YT2452
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$150.00
3 weeks
0
Add to cart
Collected
Collect
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