The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Product List
Catalog
Product
Reactivity
Applications
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CD80 Rabbit pAb
Human,Mouse
IHC,IF,ELISA
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CD80 Mouse mAb
Human
IHC,IF,ELISA
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CD19 (PTR1379) recombinant Mouse mAb
Human
Flow Cyt,ELISA
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CD86 (PT0048R) PT® Rabbit mAb
Mouse,
WB,IHC,IF,IP,ELISA
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CD86 Rabbit pAb
Human,Mouse
WB,IF,ELISA
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CD184 (PN0297) Nb-FC recombinant antibody
Human
ELISA
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CD134 (PN0303) Nb-FC recombinant antibody
Human
ELISA
-
CD48 (PN0205) Nb-FC recombinant antibody
Human
ELISA,Flow Cyt
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CD45RO (PN0524) Nb-FC recombinant antibody
Human
ELISA,Flow Cyt
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CD27 (PN0428) Nb-FC recombinant antibody
Human
Flow Cyt,ELISA