SNAI2 rabbit pAb

  • Catalog No.:YT7985
  • Applications:WB, ELISA
  • Reactivity:Human,Mouse,Rat
    • Gene Name:
    • SNAI2 SLUG SLUGH
    • Protein Name:
    • SNAI2
    • Human Gene Id:
    • 6591
    • Human Swiss Prot No:
    • O43623
    • Mouse Swiss Prot No:
    • P97469
    • Immunogen:
    • Synthesized peptide derived from human SNAI2
    • Specificity:
    • This antibody detects endogenous levels of Human,Mouse,Rat SNAI2
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Polyclonal Rabbit
    • Dilution:
    • WB 1:1000-2000 ELISA 1:5000-20000
    • Purification:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2)
    • MolecularWeight(Da):
    • 29480
    • Observed Band(KD):
    • 30
    • Background:
    • snail family transcriptional repressor 2(SNAI2) Homo sapiens This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008],
    • Function:
    • disease:Defects in SNAI2 are a cause of neural tube defects (NTD).,disease:Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.,function:Transcriptional repressor. Involved in the generation and migration of neural crest cells.,similarity:Belongs to the snail C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,tissue specificity:Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.,