SRA1 rabbit pAb

  • Catalog No.:YT7810
  • Applications:WB;ELISA
  • Reactivity:Human;Rat;Mouse;
    • Target:
    • SRA1
    • Gene Name:
    • SRA1 PP7684
    • Protein Name:
    • SRA1
    • Human Swiss Prot No:
    • Q9HD15
    • Mouse Swiss Prot No:
    • Q80VJ2
    • Immunogen:
    • Synthesized peptide derived from human SRA1
    • Specificity:
    • This antibody detects endogenous levels of Human SRA1
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:1000-2000 ELISA 1:5000-20000
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name:
    • Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein;SRAP)
    • Molecular Weight(Da):
    • 26kD
    • Background:
    • Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012],
    • Function:
    • function:Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.,miscellaneous:Appears to be the first example of a new class of functional RNAs also able to encode a protein.,similarity:Belongs to the SRA1 family.,subunit:SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.,tissue specificity:Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Als
    • Subcellular Location:
    • Nucleus . Cytoplasm .
    • Expression:
    • Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus.