SRA1 rabbit pAb
- Catalog No.:YT7810
- Applications:WB;ELISA
- Reactivity:Human;Rat;Mouse;
- Target:
- SRA1
- Gene Name:
- SRA1 PP7684
- Protein Name:
- SRA1
- Human Gene Id:
- 10011
- Human Swiss Prot No:
- Q9HD15
- Mouse Gene Id:
- 24068
- Mouse Swiss Prot No:
- Q80VJ2
- Rat Gene Id:
- 252891
- Rat Swiss Prot No:
- Q6QGW5
- Immunogen:
- Synthesized peptide derived from human SRA1
- Specificity:
- This antibody detects endogenous levels of Human SRA1
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:1000-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein;SRAP)
- Molecular Weight(Da):
- 26kD
- Background:
- Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012],
- Function:
- function:Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.,miscellaneous:Appears to be the first example of a new class of functional RNAs also able to encode a protein.,similarity:Belongs to the SRA1 family.,subunit:SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.,tissue specificity:Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Als
- Subcellular Location:
- Nucleus . Cytoplasm .
- Expression:
- Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus.
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