BMP-2 Polyclonal Antibody

  • Catalog No.:YT5651
  • Applications:IF;WB;IHC;ELISA
  • Reactivity:Human;Mouse;Rat
    • Target:
    • BMP-2
    • Fields:
    • >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Pathways in cancer;>>Basal cell carcinoma
    • Gene Name:
    • BMP2
    • Protein Name:
    • Bone morphogenetic protein 2
    • Human Gene Id:
    • 650
    • Human Swiss Prot No:
    • P12643
    • Mouse Swiss Prot No:
    • P21274
    • Immunogen:
    • Synthesized peptide derived from Bone morphogenetic protein 2 at AA range: 341-390
    • Specificity:
    • BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • IF 1:50-200 WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000. Not yet tested in other applications.
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name:
    • BMP2;BMP2A;Bone morphogenetic protein 2;BMP-2;Bone morphogenetic protein 2A;BMP-2A
    • Observed Band(KD):
    • 44kD
    • Background:
    • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016],
    • Function:
    • function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.,
    • Subcellular Location:
    • Secreted.
    • Expression:
    • Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.