Integrin β2 Polyclonal Antibody

    • Catalog No.:YT5461
    • Applications:WB,ELISA
    • Reactivity:Human
      • Gene Name:
      • ITGB2
      • Protein Name:
      • Integrin beta-2
      • Human Gene Id:
      • 3689
      • Human Swiss Prot No:
      • P05107
      • Mouse Swiss Prot No:
      • P11835
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from the Internal region of human ITGB2. AA range:621-670
      • Specificity:
      • Integrin β2 Polyclonal Antibody detects endogenous levels of Integrin β2 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD18
      • MolecularWeight(Da):
      • 84782
      • Observed Band(KD):
      • 95
      • Background:
      • integrin subunit beta 2(ITGB2) Homo sapiens This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
      • Function:
      • disease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on S
      • Subcellular Location:
      • plasma membrane,integrin complex,cell surface,membrane,integrin alphaL-beta2 complex,receptor complex,extracellular exosome,extracellular vesicle,
      • Expression:
      • Blood,Liver,Muscle,Plasma,Spleen,
      • Products Images
      • Western Blot analysis of HeLa cells using Integrin β2 Polyclonal Antibody. Antibody was diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Western Blot analysis of KB-UV Hela using Integrin β2 Polyclonal Antibody diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000