Unc18-1 Polyclonal Antibody

    • Catalog No.:YT4822
    • Applications:IHC;IF;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • Unc18-1
      • Fields:
      • >>Synaptic vesicle cycle
      • Gene Name:
      • STXBP1
      • Protein Name:
      • Syntaxin-binding protein 1
      • Human Gene Id:
      • 6812
      • Human Swiss Prot No:
      • P61764
      • Mouse Swiss Prot No:
      • O08599
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human MUNC-18a. AA range:279-328
      • Specificity:
      • Unc18-1 Polyclonal Antibody detects endogenous levels of Unc18-1 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • STXBP1;UNC18A;Syntaxin-binding protein 1;MUNC18-1;N-Sec1;Protein unc-18 homolog 1;Unc18-1;Protein unc-18 homolog A;Unc-18A;p67
      • Molecular Weight(Da):
      • 68kD
      • Background:
      • This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010],
      • Function:
      • disease:Defects in STXBP1 are the cause of early infantile epileptic encephalopathy type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.,function:May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.,similarity:Belongs to the STXBP/unc-18/SEC1 family.,subunit:Binds SYTL4 and STX1A.,tissue specificity:Brain and spinal cord. Highly enriched in axons.,
      • Subcellular Location:
      • Cytoplasm, cytosol . Membrane; Peripheral membrane protein.
      • Expression:
      • Brain and spinal cord. Highly enriched in axons.
      • Products Images
      • Immunofluorescence analysis of NIH/3T3 cells, using MUNC-18a Antibody. The picture on the right is blocked with the synthesized peptide.
      • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MUNC-18a Antibody. The picture on the right is blocked with the synthesized peptide.