Tyk 2 Polyclonal Antibody

    • Catalog No.:YT4791
    • Applications:WB,IHC-p,IF/ICC,ELISA
    • Reactivity:Human,Mouse,Monkey
      • Gene Name:
      • TYK2
      • Protein Name:
      • Non-receptor tyrosine-protein kinase TYK2
      • Human Gene Id:
      • 7297
      • Human Swiss Prot No:
      • P29597
      • Mouse Swiss Prot No:
      • Q9R117
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human TYK2. AA range:1020-1069
      • Specificity:
      • Tyk 2 Polyclonal Antibody detects endogenous levels of Tyk 2 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • TYK2; Non-receptor tyrosine-protein kinase TYK2
      • MolecularWeight(Da):
      • 133650
      • Observed Band(KD):
      • 134
      • Background:
      • tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],
      • Function:
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also called autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. The syndrome consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.,online information:TYK2 mutation db,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Conta
      • Subcellular Location:
      • nucleus,cytoplasm,cytosol,cytoskeleton,membrane,extrinsic component of cytoplasmic side of plasma membrane,extracellular exosome,
      • Expression:
      • Brain,Kidney,
      • Products Images
      • Western Blot analysis of various cells using Tyk 2 Polyclonal Antibody diluted at 1:2000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Immunofluorescence analysis of COS7 cells, using TYK2 Antibody. The picture on the right is blocked with the synthesized peptide.
      • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TYK2 Antibody. The picture on the right is blocked with the synthesized peptide.
      • Western blot analysis of lysates from 293 and COS7 cells, treated with heat shock, using TYK2 Antibody. The lane on the right is blocked with the synthesized peptide.