• Target：
• TBX3

• Fields：
• >>Signaling pathways regulating pluripotency of stem cells

• Gene Name：
• TBX3

• Protein Name：
• T-box transcription factor TBX3

• Human Gene Id：
• 6926

• Human Swiss Prot No：
• O15119

• Mouse Gene Id：
• 21386

• Mouse Swiss Prot No：
• P70324

• Rat Gene Id：
• 353305

• Rat Swiss Prot No：
• Q7TST9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TBX3. AA range:301-350

• Specificity：
• TBX3 Polyclonal Antibody detects endogenous levels of TBX3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TBX3;T-box transcription factor TBX3;T-box protein 3

• Observed Band(KD)：
• 79kD

• Background：
• This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.,function:Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Widely expressed.,

• Subcellular Location：
• Nucleus .

• Expression：
• Widely expressed.

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