Six1 Polyclonal Antibody

    • Catalog No.:YT4305
    • Applications:WB;ELISA;IHC
    • Reactivity:Human;Mouse
      • Target:
      • Six1
      • Fields:
      • >>Transcriptional misregulation in cancer
      • Gene Name:
      • SIX1
      • Protein Name:
      • Homeobox protein SIX1
      • Human Gene Id:
      • 6495
      • Human Swiss Prot No:
      • Q15475
      • Mouse Swiss Prot No:
      • Q62231
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human SIX1. AA range:111-160
      • Specificity:
      • Six1 Polyclonal Antibody detects endogenous levels of Six1 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • SIX1;Homeobox protein SIX1;Sine oculis homeobox homolog 1
      • Observed Band(KD):
      • 33kD
      • Background:
      • The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008],
      • Function:
      • disease:Defects in SIX1 are the cause of autosomal dominant deafness type 23 (DFNA23) [MIM:605192].,disease:Defects in SIX1 are the cause of branchiootic syndrome type 3 (BOS3) [MIM:608389]. Urinary tract malformations constitute the most frequent cause of chronic renal failure in the first two decades of life. Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder of kidney and urinary tract malformations with hearing loss. The major feature of BOR is hearing loss (93% of patients), which can be conductive, sensorineural, or both and varies in age of onset.,function:May be involved in limb tendon and ligament development.,similarity:Belongs to the SIX/Sine oculis homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Specifically expressed in skeletal muscle.,
      • Subcellular Location:
      • Nucleus . Cytoplasm.
      • Expression:
      • Specifically expressed in skeletal muscle.
      • Products Images
      • Western blot analysis of SIX1 Antibody. The lane on the right is blocked with the SIX1 peptide.
      • Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).